biochemistry

Investigation of the Roles of fshr-1 and sphk-1 on Life History Traits in C. elegans

Abstract The later years of life are often characterized by declining cognitive function and mobility. One contributor is the cellular accumulation of reactive oxygen species (ROS). However, our understanding of how cells respond to ROS to promote health and survival is incomplete. We focused here on two genes, follicle stimulating hormone receptor-1 (fshr-1) and sphingosine …

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Effects of Binding Pocket Mutations on Substrate Specificity and Enzyme Efficiency of BS2 esterase

Introduction           Serine hydrolases are one of the largest groups of enzymes and the most commonly used for biocatalysts. They are identified by the presence of a highly nucleophilic serine residue within the catalytic triad or dyad that hydrolyze substrates (Kazlauskas). BS2 from bacteria Bacillus subtilis is one known serine hydrolase that has an unselective …

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